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  • Sign in to gain access to subscriptions and/or my tools. Sign in | my tools | contact us | help search all journals advanced search search history browse journals skip to main page content home onlinefirst all issues subscribe rss email alerts search this journal advanced journal search â» immunohistochemical characterization of spontaneous and acrylonitrile-induced brain tumors in the rat holly meredith kolenda-roberts hroberts{at}epl-inc. Com epl inc. , research triangle park, north carolina, usa nancy harris epl inc. , research triangle park, north carolina, usa emily singletary epl inc. , research triangle park, north carolina, usa jerry f. Hardisty epl inc. , research triangle park, north carolina, usa abstract twenty-eight spontaneously occurring glial tumors (previously diagnosed as astrocytomas, oligodendrogliomas, and gliomas) and eleven granular cell tumors (gcts) were selected for evaluation using a panel of immunohistochemistry (ihc) stains (ricinus communis agglutinin type 1 [rca-1], ionized calcium-binding adapter molecule 1 [iba-1], ox-6/major immunohistocompatibility complex class ii, oligodendrocytes transcription factor 2 [olig2], glial fibrillary acidic protein [gfap], s100 beta, glutamine synthetase, neurofilament, proliferating cell nuclear antigen). In addition, nine brain tumors from a 2-year drinking water study for acrylonitrile were obtained from the acrylonitrile group, inc. Based on ihc staining characteristics, olig2+ oligodendrogliomas were the most commonly diagnosed spontaneous tumor in these animals. cheap generic viagra viagra for sale viagra without a doctor prescription http://medicaresupplementspecialists.com/pfz-sale-viagra-rp/ buy viagra viagra for sale buy cheap viagra viagra without a doctor prescription cheap viagra online viagra online Many of the spontaneous tumors previously diagnosed as astrocytomas were rca-1+, iba-1+ and negative for gfap, s100beta, and glutamine synthetase; the diagnosis of malignant microglial tumor is proposed for these neoplasms. Three mixed tumors were identified with olig2+ (oligodendrocytes) and iba-1+ (macrophage/microglia) cell populations. The term mixed glioma is not recommended for these tumors, as it is generally used to refer to oligoastrocytomas, which were not observed in this study. Gct were positive for rca-1 and iba-1. All acrylonitrile tumors were identified as malignant microglial tumors. These results may indicate that oligodendrogliomas are more common as spontaneous tumors, while acrylonitrile-induced neoplasms are microglial/histiocytic in origin. No astrocytomas (gfap, s100 beta, and/or glutamine synthetase-positive neoplasms) were observed. â© 2012 society of toxicologic pathology citeulike connotea delicious digg facebook google+ linkedin mendeley reddit stumbleupon technorati twitter what's this? No related web pages this article published online before print july 2. Uvođenjem električnih instalacija u nove stambene i poslovne objekte
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